Cryptoliteratuurtip: Testing Treatments
oktober 29, 2011 Een reactie plaatsen
Vijf jaar geleden brachten Imogen Evans, Hazel Thornton, Iain Chalmers en Paul Glasziou de eerste editie van Testing Treatments (Better Research for Better Healthcare) uit. Een verhelderend boek over de vraag hoe we weten of een behandeling werkt. Ben Goldacre schreef voor de nieuwe editie (oktober 2011) het voorwoord.
Medicine shouldn’t be about authority, and the most important question anyone can ask on any claim is simple: ‘how do you know?’ This book is about the answer to that question.
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In Chapter 1 we briefly describe why fair tests of treatments are necessary and how some new treatments have had harmful effects that were unexpected.
In Chapter 2 we describe how the hoped-for effects of other treatments have failed to materialize, and highlight the fact that many commonly used treatments have not been adequately evaluated.
Chapter 3 illustrates why more intensive treatment is not necessarily better.
Chapter 4 explains why screening healthy people for early indications of disease may be harmful as well as helpful.
In Chapter 5 we highlight some of the many uncertainties that pervade almost every aspect of healthcare and explain how to tackle them.
Chapters 6, 7, and 8 give some ‘technical details’ in a nontechnical way. In Chapter 6 we outline the basis for fair testing of treatments, emphasizing the importance of ensuring that like is compared with like. Chapter 7 highlights why taking into account the play of chance is essential. Chapter 8 explains why it is so important to assess all the relevant reliable evidence systematically.
Chapter 9 outlines why systems for regulating research into the effects of treatments, through research ethics committees and other bodies, can put obstacles in the way of getting good research done, and explains why regulation may therefore fail to promote the interests of patients.
Chapter 10 contrasts the key differences between good, bad, and unnecessary research into the effects of treatments; it points out how research is often distorted by commercial and academic priorities and fails to address issues that are likely to make a real difference to the well-beingof patients.
Chapter 11 maps what patients and the public can do to ensure better testing of treatments.
In Chapter 12 we look at ways in which robust evidence from research into treatments can really make for better healthcare for individual patients.
And in Chapter 13 we present our blueprint for a better future, ending with an action plan.
Each chapter is referenced with a selection of key source material, and a separate Additional Resources section is included at the end of the book (see p184).
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